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During this period Dr La Fontaine fee fundamental advances into the molecular basis of copper homeostasis, illuminating the complexities of the biochemistry and cell biology of the copper-ATPases and how defects in these proteins lead to the devastating effects seen in the genetically inherited copper deficiency and toxicity disorders, Menkes and Wilson diseases, respectively.
Wright Free jewish singles websites in Australia to establish a new program of research: elucidating copper protein networks for a holistic understanding of the proteins and pathways that contribute to cellular copper handling.
Copper is an essential shsdi metal involved in a wide variety of physiological and pathological processes. It has become clear that copper regulatory pathways are corrupted Online shadi in Warrnambool free conditions that include neurodegenerative diseases and cancer leading to dysregulated copper levels, but the molecular basis of the link between copper and disease is still unclear.
Current Research Interests: 1. Copper regulatory proteins at the interface of copper homeostasis and redox biology. The role of copper proteins in neuroprotection. Molecular mechanisms of glutaredoxin enzymes: versatile hubs for thiol-disulfide exchange between protein thiols and glutathione. High-resolution crystal structure of the reduced Grx1 from Saccharomyces cerevisiae. Copper accumulation in senescent cells: Interplay between copper transporters and impaired autophagy.
Comparative microarray analysis identifies commonalities in neuronal injury: evidence for oxidative stress, dysfunction of calcium signalling, and inhibition of autophagy-lysosomal pathway.
Reduced glutathione biosynthesis in Drosophila melanogaster causes neuronal defects linked Watrnambool copper deficiency. Targeting copper in cancer therapy: 'copper that cancer'. Glutaredoxin1 protects neuronal cells from copper-induced toxicity.
Gene expression profiling of rotenone-mediated cortical neuronal death: Evidence for inhibition of ubiquitin-proteasome system and autophagy-lysosomal pathway, and dysfunction of mitochondrial and calcium signaling.
Increasing intracellular bioavailable copper selectively targets prostate cancer cells. Links between copper and cholesterol in Alzheimer's disease. Unification of the copper I binding affinities of the metallo-chaperones Sgadi, Atox1, and related proteins: Detection probes and affinity standards. Intracellular copper deficiency increases amyloid-? Investigating copper-regulated protein expression in Menkes fibroblasts using antibody microarrays.
ATP7B mediates vesicular sequestration of copper: insight into biliary copper excretion. Intracellular trafficking of Speed dating Sydney berkshire human Wilson protein: The role of the six N-terminal metal-binding sites.
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